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GLP-1 triggers which of the following in the brain?


A) decreased satiety
B) decreased food intake
C) decreased body weight
D) All of the answers are correct.
E) decreased food intake and decreased body weight

F) A) and E)
G) B) and E)

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Maintenance of a constant blood-glucose level is called


A) glucose tolerance.
B) glucose adjustment.
C) glucose homeostasis.
D) cholecystokinin.
E) None of the answers is correct.

F) D) and E)
G) None of the above

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What is the cause of type 1 diabetes?

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This form of diabetes appears ...

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What is the advantage of converting pyruvate to lactate in skeletal muscle?

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One advantage is that NAD+ is regenerated...

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What is the primary source of energy used by the muscle during starvation?


A) glucose
B) lactate
C) fatty acids
D) ketone bodies
E) branched-chain amino acids

F) C) and D)
G) A) and E)

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Which organ is considered to be the metabolic "hub" of the body?


A) brain
B) small intestine
C) liver
D) pancreas
E) adipose tissue

F) A) and C)
G) B) and E)

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How do SOCS (suppressors of cytokine signaling)proteins inhibit receptor signaling? Give one example.

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SOCS proteins bind to phosphorylated tyr...

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What are the plasma concentrations of glucose in the normal fasting and starvation states?

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Typical fasting glucose level ...

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What are some of the primary metabolic fates of acetyl CoA in animals?

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Acetyl CoA can enter the citric acid cyc...

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The microsomal ethanol-oxidizing system (MEOS)consumes oxygen and ______________,which leads to oxidative stress partly due to the inability to regenerate glutathione.

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Which of the following metabolic conversions provides the maximum rate of ATP production (mmol sec-1) for muscle contraction?


A) muscle glycogen to CO2
B) muscle glycogen to lactate
C) creatine phosphate and ADP to ATP and creatine
D) fatty acid to CO2
E) liver glycogen to CO2

F) C) and D)
G) A) and B)

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C

The primary function of aerobic glycolysis is to


A) degrade glucose to provide ATP.
B) provide carbon skeletons for biosynthesis.
C) provide NADH for lactate reduction.
D) provide NADPH for biosynthetic reactions
E) None of the answers is correct.

F) D) and E)
G) C) and E)

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What metabolic changes occur during the early fasting state?

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In the initial hours after a meal,the bl...

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The "fed state" leads to the release of the hormone ____________________.

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What fuel is used exclusively by muscles following a day of starvation?


A) glycogen
B) fatty acids
C) alanine
D) glucose
E) β\beta -hydroxybutyrate

F) B) and E)
G) D) and E)

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B

Excess alcohol consumption can lead to Wernicke-Korsaff syndrome due to the lack of the vitamin thiamine.Which of the following metabolic conversions CANNOT occur in the absence of thiamine?


A) pyruvate + CO2 \rarr oxaloacetate
B) pyruvate \rarr acetyl-CoA + CO2
C) α\alpha -ketoglutarate \rarr succinyl-CoA + CO2
D) phosphoenolpyruvate + CO2 \rarr oxaloacetate
E) B and C are correct.

F) A) and E)
G) C) and D)

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What is the key regulatory enzyme in glycolysis?


A) phosphofructokinase
B) glucokinase
C) hexokinase
D) triose phosphate isomerase
E) None of the answers is correct.

F) B) and E)
G) B) and C)

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What is the major fuel for resting muscle,and what it the major fuel for muscle under strenuous work conditions?

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Fatty acids are the major fuel...

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What hormone,released by adipose tissue,generates a sense of satiation and inhibits the appetite?


A) leptin
B) cholecystokinin
C) neuropeptide Y
D) insulin
E) None of the answers is correct.

F) B) and C)
G) A) and E)

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A

When levels of ketone bodies are high,the _________________ can no longer maintain acid-base balance in the blood.

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